Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. Coccinia grandis has been used in traditional medicine as a household remedy for various diseases. The whole plant of Coccinia grandis having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive, mutagenic. The present review gives botany, chemical constituents and pharmacological activities of coccinia grandis. This study was aimed to investigate the antidiabetic activities of methanolic extract of leaves, fruits, root and aerial part of Coccinia grandis in alloxan induced diabetic mice. Diabetes was confirmed after 25 days of single intraperitoneal injection of alloxan (150 mg/kg) in albino mice. Different groups of diabetic animals were treated with crude plant extract of 150 mg/kg , 300 mg/kg, 400 mg /kg respectively orally administered for a period of 8 hours. The blood sugar level was monitored after 2 hour, after 4 hour, after 6 hour and after 8 hour respectively. The antidiabetic effect of crude plant extract was compared with Glibenclamide (10 mg/kg) belongs to the group of oral hypoglycemic. Our study indicate that, the root, fruit, leaf and aerial part of plant extract (150 mg/kg) reduce the blood glucose level after 8th hour 7.87±0.35, 17.9±12.18, 19.5±7.04 and 23.7±7.23 respectively. The root, fruit, leaf and aerial part of plant extract (300 mg/kg) reduce the blood glucose level after 8th hour 18±12, 19.6±11.6, 20.1±1.55 and 15.3±1.28 respectively. The root, fruit, leaf and aerial part of plant extract (450 mg/kg) reduce the blood glucose level after 8th hour 16.2±1.08, 9.4±0.46, 14.3±1.31 and 10.4±1.56 respectively. Glibenclamide (10 mg/kg) reduces the blood glucose level 11.27±4.64. From this study, it was revealed that different part of Coccinia grandis plant extract has potential antidiabetic activity.
| Published in |
Journal of Plant Sciences (Volume 2, Issue 6-1)
This article belongs to the Special Issue Pharmacological and Biological Investigation of Medicinal Plants |
| DOI | 10.11648/j.jps.s.2014020601.14 |
| Page(s) | 19-23 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Alloxan, Coccinia grandis, Diabetes Mellitus, Glibenclamide, Hypoglycemic Activity
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APA Style
Md. Ataur Rahman, Jyotirmoy Sarker, Shamima Akter, Abdullah Al Mamun, Md. Abul Kalam Azad, et al. (2015). Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis. Journal of Plant Sciences, 2(6-1), 19-23. https://doi.org/10.11648/j.jps.s.2014020601.14
ACS Style
Md. Ataur Rahman; Jyotirmoy Sarker; Shamima Akter; Abdullah Al Mamun; Md. Abul Kalam Azad, et al. Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis. J. Plant Sci. 2015, 2(6-1), 19-23. doi: 10.11648/j.jps.s.2014020601.14
AMA Style
Md. Ataur Rahman, Jyotirmoy Sarker, Shamima Akter, Abdullah Al Mamun, Md. Abul Kalam Azad, et al. Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis. J Plant Sci. 2015;2(6-1):19-23. doi: 10.11648/j.jps.s.2014020601.14
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Download@article{10.11648/j.jps.s.2014020601.14,
author = {Md. Ataur Rahman and Jyotirmoy Sarker and Shamima Akter and Abdullah Al Mamun and Md. Abul Kalam Azad and Md. Mohiuddin and Seuly Akter and Md. Shahid Sarwar},
title = {Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis},
journal = {Journal of Plant Sciences},
volume = {2},
number = {6-1},
pages = {19-23},
doi = {10.11648/j.jps.s.2014020601.14},
url = {https://doi.org/10.11648/j.jps.s.2014020601.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2014020601.14},
abstract = {Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. Coccinia grandis has been used in traditional medicine as a household remedy for various diseases. The whole plant of Coccinia grandis having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive, mutagenic. The present review gives botany, chemical constituents and pharmacological activities of coccinia grandis. This study was aimed to investigate the antidiabetic activities of methanolic extract of leaves, fruits, root and aerial part of Coccinia grandis in alloxan induced diabetic mice. Diabetes was confirmed after 25 days of single intraperitoneal injection of alloxan (150 mg/kg) in albino mice. Different groups of diabetic animals were treated with crude plant extract of 150 mg/kg , 300 mg/kg, 400 mg /kg respectively orally administered for a period of 8 hours. The blood sugar level was monitored after 2 hour, after 4 hour, after 6 hour and after 8 hour respectively. The antidiabetic effect of crude plant extract was compared with Glibenclamide (10 mg/kg) belongs to the group of oral hypoglycemic. Our study indicate that, the root, fruit, leaf and aerial part of plant extract (150 mg/kg) reduce the blood glucose level after 8th hour 7.87±0.35, 17.9±12.18, 19.5±7.04 and 23.7±7.23 respectively. The root, fruit, leaf and aerial part of plant extract (300 mg/kg) reduce the blood glucose level after 8th hour 18±12, 19.6±11.6, 20.1±1.55 and 15.3±1.28 respectively. The root, fruit, leaf and aerial part of plant extract (450 mg/kg) reduce the blood glucose level after 8th hour 16.2±1.08, 9.4±0.46, 14.3±1.31 and 10.4±1.56 respectively. Glibenclamide (10 mg/kg) reduces the blood glucose level 11.27±4.64. From this study, it was revealed that different part of Coccinia grandis plant extract has potential antidiabetic activity.},
year = {2015}
}
TY - JOUR T1 - Comparative Evaluation of Antidiabetic Activity of Crude Methanolic Extract of Leaves, Fruits, Roots and Aerial Parts of Coccinia grandis AU - Md. Ataur Rahman AU - Jyotirmoy Sarker AU - Shamima Akter AU - Abdullah Al Mamun AU - Md. Abul Kalam Azad AU - Md. Mohiuddin AU - Seuly Akter AU - Md. Shahid Sarwar Y1 - 2015/03/14 PY - 2015 N1 - https://doi.org/10.11648/j.jps.s.2014020601.14 DO - 10.11648/j.jps.s.2014020601.14 T2 - Journal of Plant Sciences JF - Journal of Plant Sciences JO - Journal of Plant Sciences SP - 19 EP - 23 PB - Science Publishing Group SN - 2331-0731 UR - https://doi.org/10.11648/j.jps.s.2014020601.14 AB - Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. Coccinia grandis has been used in traditional medicine as a household remedy for various diseases. The whole plant of Coccinia grandis having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive, mutagenic. The present review gives botany, chemical constituents and pharmacological activities of coccinia grandis. This study was aimed to investigate the antidiabetic activities of methanolic extract of leaves, fruits, root and aerial part of Coccinia grandis in alloxan induced diabetic mice. Diabetes was confirmed after 25 days of single intraperitoneal injection of alloxan (150 mg/kg) in albino mice. Different groups of diabetic animals were treated with crude plant extract of 150 mg/kg , 300 mg/kg, 400 mg /kg respectively orally administered for a period of 8 hours. The blood sugar level was monitored after 2 hour, after 4 hour, after 6 hour and after 8 hour respectively. The antidiabetic effect of crude plant extract was compared with Glibenclamide (10 mg/kg) belongs to the group of oral hypoglycemic. Our study indicate that, the root, fruit, leaf and aerial part of plant extract (150 mg/kg) reduce the blood glucose level after 8th hour 7.87±0.35, 17.9±12.18, 19.5±7.04 and 23.7±7.23 respectively. The root, fruit, leaf and aerial part of plant extract (300 mg/kg) reduce the blood glucose level after 8th hour 18±12, 19.6±11.6, 20.1±1.55 and 15.3±1.28 respectively. The root, fruit, leaf and aerial part of plant extract (450 mg/kg) reduce the blood glucose level after 8th hour 16.2±1.08, 9.4±0.46, 14.3±1.31 and 10.4±1.56 respectively. Glibenclamide (10 mg/kg) reduces the blood glucose level 11.27±4.64. From this study, it was revealed that different part of Coccinia grandis plant extract has potential antidiabetic activity. VL - 2 IS - 6-1 ER -
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