Background: Cardiovascular diseases are common in hemodialysis (HD) patients and cardiovascular mortality is responsible for 50% of overall deaths in these patients. Epicardial fat thickness (EpFT) may be an effective marker for the prediction of cardiovascular diseases in hemodialysis patients. The thickness of EpF can be measured by echocardiography that can accurately estimate the actual amount of EpF. The aim of the current study is to assess the association between EpFT and carotid intima-media thickness (CIMT), left ventricular systolic and diastolic function and left ventricular mass index in patients with chronic kidney disease (CKD) undergoing hemodialysis to clarify the relationships between EpF and cardiovascular disease risk in these patients. Materials and Methods: Forty adult uremic patients from dialysis unit and twenty (age and sex matched) healthy control subjects were included in this study. Clinical evaluation, routine laboratory investigations, echocardiographic study including measurement of EpFT and carotid Duplex to estimate CIMT were done to all subjects. Results: we found highly significant increase in serum C-reactive protein and significant increase in serum phosphorus and triglyceride with significant decrease in serum calcium and high-density lipoprotein cholesterol in hemodialysis patients compared to the controls. Also, there were significant increases in left ventricular mass index, left atrium diameter, carotid intima-media thickness, epicardial fat thickness, peak velocity of the late filling wave due to atrial contraction (A wave) and deceleration time of E wave in hemodialysis patients compared to the controls. There were also highly significant decrease in E/A ratio in hemodialysis patients compared to healthy control subjects. EpFT measured by echocardiography in hemodialysis patients was positively correlated with body mass index, CRP, left atrium diameter, left ventricular mass index, deceleration time and CIMT and negatively correlated with high-density lipoprotein cholesterol and E/A ratio. Conclusion: Hemodialysis patients can be evaluated routinely by echocardiography for early detection of cardiovascular structural and functional changes which are common in these patients and epicardial fat thickness is an effective marker for the prediction of cardiovascular risk in hemodialysis patients.
| Published in | American Journal of Internal Medicine (Volume 3, Issue 3) |
| DOI | 10.11648/j.ajim.20150303.12 |
| Page(s) | 86-94 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Hemodialysis Patients, Cardiovascular Diseases, Carotid Intima-Media Thickness, Epicardial Fat Thickness
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APA Style
Ashraf Abd El-Khalik Barakat, Fatma Mohammed Nasr, Amna Ahmed Metwaly, Manar Abd El-Rouf Raafat Ameen. (2015). Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients. American Journal of Internal Medicine, 3(3), 86-94. https://doi.org/10.11648/j.ajim.20150303.12
ACS Style
Ashraf Abd El-Khalik Barakat; Fatma Mohammed Nasr; Amna Ahmed Metwaly; Manar Abd El-Rouf Raafat Ameen. Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients. Am. J. Intern. Med. 2015, 3(3), 86-94. doi: 10.11648/j.ajim.20150303.12
AMA Style
Ashraf Abd El-Khalik Barakat, Fatma Mohammed Nasr, Amna Ahmed Metwaly, Manar Abd El-Rouf Raafat Ameen. Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients. Am J Intern Med. 2015;3(3):86-94. doi: 10.11648/j.ajim.20150303.12
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Download@article{10.11648/j.ajim.20150303.12,
author = {Ashraf Abd El-Khalik Barakat and Fatma Mohammed Nasr and Amna Ahmed Metwaly and Manar Abd El-Rouf Raafat Ameen},
title = {Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients},
journal = {American Journal of Internal Medicine},
volume = {3},
number = {3},
pages = {86-94},
doi = {10.11648/j.ajim.20150303.12},
url = {https://doi.org/10.11648/j.ajim.20150303.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150303.12},
abstract = {Background: Cardiovascular diseases are common in hemodialysis (HD) patients and cardiovascular mortality is responsible for 50% of overall deaths in these patients. Epicardial fat thickness (EpFT) may be an effective marker for the prediction of cardiovascular diseases in hemodialysis patients. The thickness of EpF can be measured by echocardiography that can accurately estimate the actual amount of EpF. The aim of the current study is to assess the association between EpFT and carotid intima-media thickness (CIMT), left ventricular systolic and diastolic function and left ventricular mass index in patients with chronic kidney disease (CKD) undergoing hemodialysis to clarify the relationships between EpF and cardiovascular disease risk in these patients. Materials and Methods: Forty adult uremic patients from dialysis unit and twenty (age and sex matched) healthy control subjects were included in this study. Clinical evaluation, routine laboratory investigations, echocardiographic study including measurement of EpFT and carotid Duplex to estimate CIMT were done to all subjects. Results: we found highly significant increase in serum C-reactive protein and significant increase in serum phosphorus and triglyceride with significant decrease in serum calcium and high-density lipoprotein cholesterol in hemodialysis patients compared to the controls. Also, there were significant increases in left ventricular mass index, left atrium diameter, carotid intima-media thickness, epicardial fat thickness, peak velocity of the late filling wave due to atrial contraction (A wave) and deceleration time of E wave in hemodialysis patients compared to the controls. There were also highly significant decrease in E/A ratio in hemodialysis patients compared to healthy control subjects. EpFT measured by echocardiography in hemodialysis patients was positively correlated with body mass index, CRP, left atrium diameter, left ventricular mass index, deceleration time and CIMT and negatively correlated with high-density lipoprotein cholesterol and E/A ratio. Conclusion: Hemodialysis patients can be evaluated routinely by echocardiography for early detection of cardiovascular structural and functional changes which are common in these patients and epicardial fat thickness is an effective marker for the prediction of cardiovascular risk in hemodialysis patients.},
year = {2015}
}
TY - JOUR T1 - Correlation Between Epicardial Fat Thickness and Cardiovascular Risk in Hemodialysis Patients AU - Ashraf Abd El-Khalik Barakat AU - Fatma Mohammed Nasr AU - Amna Ahmed Metwaly AU - Manar Abd El-Rouf Raafat Ameen Y1 - 2015/03/26 PY - 2015 N1 - https://doi.org/10.11648/j.ajim.20150303.12 DO - 10.11648/j.ajim.20150303.12 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 86 EP - 94 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20150303.12 AB - Background: Cardiovascular diseases are common in hemodialysis (HD) patients and cardiovascular mortality is responsible for 50% of overall deaths in these patients. Epicardial fat thickness (EpFT) may be an effective marker for the prediction of cardiovascular diseases in hemodialysis patients. The thickness of EpF can be measured by echocardiography that can accurately estimate the actual amount of EpF. The aim of the current study is to assess the association between EpFT and carotid intima-media thickness (CIMT), left ventricular systolic and diastolic function and left ventricular mass index in patients with chronic kidney disease (CKD) undergoing hemodialysis to clarify the relationships between EpF and cardiovascular disease risk in these patients. Materials and Methods: Forty adult uremic patients from dialysis unit and twenty (age and sex matched) healthy control subjects were included in this study. Clinical evaluation, routine laboratory investigations, echocardiographic study including measurement of EpFT and carotid Duplex to estimate CIMT were done to all subjects. Results: we found highly significant increase in serum C-reactive protein and significant increase in serum phosphorus and triglyceride with significant decrease in serum calcium and high-density lipoprotein cholesterol in hemodialysis patients compared to the controls. Also, there were significant increases in left ventricular mass index, left atrium diameter, carotid intima-media thickness, epicardial fat thickness, peak velocity of the late filling wave due to atrial contraction (A wave) and deceleration time of E wave in hemodialysis patients compared to the controls. There were also highly significant decrease in E/A ratio in hemodialysis patients compared to healthy control subjects. EpFT measured by echocardiography in hemodialysis patients was positively correlated with body mass index, CRP, left atrium diameter, left ventricular mass index, deceleration time and CIMT and negatively correlated with high-density lipoprotein cholesterol and E/A ratio. Conclusion: Hemodialysis patients can be evaluated routinely by echocardiography for early detection of cardiovascular structural and functional changes which are common in these patients and epicardial fat thickness is an effective marker for the prediction of cardiovascular risk in hemodialysis patients. VL - 3 IS - 3 ER -
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