Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.
| Published in | American Journal of Life Sciences (Volume 3, Issue 2) |
| DOI | 10.11648/j.ajls.20150302.12 |
| Page(s) | 62-70 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Schistosoma Mansoni- Chloroform Extract of Citharexylum Quadrangular Leaves- Micronutrients
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APA Style
Ebtehal M. Farrag, Azza M. Mohamed, Shadia M. Kadry, Ahlam H. Mahmoud, Abdel-Razik H. Farrag, et al. (2015). Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice. American Journal of Life Sciences, 3(2), 62-70. https://doi.org/10.11648/j.ajls.20150302.12
ACS Style
Ebtehal M. Farrag; Azza M. Mohamed; Shadia M. Kadry; Ahlam H. Mahmoud; Abdel-Razik H. Farrag, et al. Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice. Am. J. Life Sci. 2015, 3(2), 62-70. doi: 10.11648/j.ajls.20150302.12
AMA Style
Ebtehal M. Farrag, Azza M. Mohamed, Shadia M. Kadry, Ahlam H. Mahmoud, Abdel-Razik H. Farrag, et al. Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice. Am J Life Sci. 2015;3(2):62-70. doi: 10.11648/j.ajls.20150302.12
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Download@article{10.11648/j.ajls.20150302.12,
author = {Ebtehal M. Farrag and Azza M. Mohamed and Shadia M. Kadry and Ahlam H. Mahmoud and Abdel-Razik H. Farrag and Dalia B. Fayed},
title = {Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice},
journal = {American Journal of Life Sciences},
volume = {3},
number = {2},
pages = {62-70},
doi = {10.11648/j.ajls.20150302.12},
url = {https://doi.org/10.11648/j.ajls.20150302.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150302.12},
abstract = {Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.},
year = {2015}
}
TY - JOUR T1 - Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice AU - Ebtehal M. Farrag AU - Azza M. Mohamed AU - Shadia M. Kadry AU - Ahlam H. Mahmoud AU - Abdel-Razik H. Farrag AU - Dalia B. Fayed Y1 - 2015/02/16 PY - 2015 N1 - https://doi.org/10.11648/j.ajls.20150302.12 DO - 10.11648/j.ajls.20150302.12 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 62 EP - 70 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20150302.12 AB - Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection. VL - 3 IS - 2 ER -
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